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Computational Biology and Biotechnology

DARPA Office: IPTO
DARPA PM: Dr. Sri Kumar

Jordan C. Feidler, Principal Investigator

Washington

Problem
A large and expanding repertoire of available physiological, biochemical, and molecular approaches has resulted in dramatic growth in the biological sciences. These advances are inherently dual-use. Although they have lowered the barrier for use in asymmetric warfare or terrorist activities, they have also demonstrated vast potential as a source for new enabling technologies.

Objectives
DARPA's BioComputation Program will develop a computational framework, BioSPICE, that facilitates the rapid construction of sophisticated simulations of intracellular processes. This system will enable researchers to rapidly explore the effects of a novel pathogen and to quickly identify possible intervention strategies. Another goal is to develop novel and useful computational architectures, sensor devices, and physical structures using biomolecules.

Activities
MITRE has had an active role in evaluating the usability, functionality, and architecture of the BioSPICE software. In addition, MITRE provides technical support in program management: evaluating current progress and identifying new areas of research that have the potential to significantly impact the program. MITRE has also staged technology demonstrations for government sponsors from multiple agencies.

Impacts
MITRE has taken a leading role in guiding one of the key scientific efforts that seeks to develop new technology for defending against biological threats. MITRE's FFRDC role has been crucial for presenting the program manager with an unbiased perspective on contributed BioSPICE software. MITRE is also facilitating the transition of developed technology to other government agencies and industry.

 

Center for Information and Technology

Michal Cenkl, Chief Engineer

Bedford and Washington

MII Research Resources
Janice Ballo (McLean) and Gayle Sobanek (Bedford), information analysts, will demonstrate several MITRE Information Infrastructure- (MII) based research resources, including Google, The Technical Exchange (TEx) and ACM Portal. These tools are available to MITRE employees from their desktops or from the kiosks in the MITRE InfoCenters. Learn how to leverage these tools by accessing the business and technical information MITRE employees need to support their work programs.

MyMII Portal
The MyMII Portal is the next phase in the evolution of the MII; the current beta pilot is available for use by all MITRE employees. Building upon the personalization provided by the MII, MyMII offers MITRE employees a customizable view of the content and services that they choose, as well as the ability to add, remove, and organize services the way they would like to see them displayed on their home page. We are also developing prototype web service applications and integrating content management variants. The experience gained through the development and implementation of Web Services will provide the groundwork for developing a technical and operational impact analysis of Web Services infrastructure.

MyMII on the Internet (eMII)
MyMII on the Internet demonstrates technology that could provide MITRE employees at sponsor sites or remote sites with the ability to access parts of the MII with only a SecurID (without having to establish a VPN connection). Services provided include access to your MITRE Time Card (TRS), the MII PhoneBook, MII Banners, and the MII Admin Menu, which is a gateway into other MII applications such as the VTC and Conference Room Schedulers. This technology investigation will be used to gauge user interest in the services offered and to solicit feedback on other services to extend beyond MITRE's firewall.

Sponsor and Team Collaboration
There has been growing demand for tools that support communities of interest (COI) both across the enterprise and with our sponsors. In an effort to find a better way of collaborating with our sponsors, the eCommunities team has been investigating the leading collaboration tool suites, such as Sharepoint Portal Server, Sharepoint Team Services, and Lotus/IBM QuickPlace, as well as Ensenyo, Livelink, eRooms and Introspective, to name a few. These tool suites support collaboration by allowing the easy sharing of documents, news, and calendar events, in addition to chat, shared whiteboard, email notifications, and other functionality. Currently, we have established communities using these tools to determine how they meet the collaboration needs of our sponsors and integrate with their current infrastructure, as well as that of the Corporation.

Remote Mail via Blackberry Enterprise Server
Email is considered by many as the true Internet killer app. Recent studies have reported that although many professionals have stated that "they can not live without email" the same group also proclaim that "keeping up with it can be an arduous task." This message is particularly true when applied to the highly mobile MITRE community. MITRE staff find themselves consistently on the road on in meetings and can quickly become overwhelmed with the amount of mail they have accumulated, and how little time they have to respond to it. In some cases, not being able to respond to email on a timely manner can have severe negative consequences, both internally and with our sponsors. The Blackberry technology exploration looks at using secure, mobile devices to convert downtime into productive time. In addition to increased productivity, the Blackberry empowers users to address concerns in a timely manner.

Voice Services for the Knowledge Worker (Voice over IP (VoIP) Infrastructure)
Over the past two years, ACIS has been evaluating a VoIP infrastructure as a part of the Advanced Infrastructure project. John Dewsnap and Stu Kroner will be presenting the results of their technology investigation to date. The demonstration will allow visitors to see how voice services have been deployed to the VoIP phones along with the current infrastructure that has been created for this project. Demonstrations will highlight services offered by these phones, including voice activated phonebook, conferencing, call screening, and myNotes. We will also discuss how these services would be beneficial to the MITRE community.

Next Generation Media Center
The Advanced Computing Environment and Intelligent
Information Access Departments have partnered to work on the Next Generation Media application. This application adds new functionality to the MITRE Media Center, such as the ability to search for words or phrases within video files that are accessible through the application. The Next Generation Media application uses Media Indexer, a COTS tool that converts speech to text, which allows users to then search on words and phrases from the presentations listed on the Web site. This new functionality should assist users in finding the information they want to view within presentations.

   

Technology Transfer Office

Gerard Eldering, Technology Transfer Office Director

Bedford and Washington

Technology transfer makes our technology affordable, supportable, and available to our government sponsors, academia, and industry. At the same time it can highlight MITRE's achievements and innovations. Technology transfer can be accomplished through a variety of means, such as licensing, cooperative research and development agreements (CRADAs), open source publishing, consortia, and industry standards. MITRE's Technology Transfer Office (TTO) can help employees develop transfer strategies, plan and execute transfers, negotiate licenses, assess risk, evaluate patent applications, and develop business plans for corporate business investments.

Over the past year, MITRE’s TTO has negotiated more than 30 licenses, established the company’s first CRADA, and fielded more than 20 intellectual property disclosures. This surge in activity is a credit to the technological advances made through MITRE’s research program.

Technology Areas

Architectures

Collaboration and Visualization

Communications and Networks

Computing and Software

Decision Support

Electronics

Human Language

Information Assurance

Information Management

Intelligent Information Processing

Investment Strategies

Modeling, Simulation, and Training

Sensors and Environment

Other Projects