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A Four-Dimensional Probabilistic Atlas of the Human Brain
2001 Award Winner
John Mazziotta
Arthur Toga
Alan Evans
Peter Fox
Jack Lancaster
Karl Zilles
Roger Woods
Tomas Paus
Gregory Simpson
Bruce Pike
Colin Holmes
Louis Collins
Paul Thompson
David MacDonald
Marco Iacoboni
Thorsten Schormann
Katrin Amunts
Nicola Palomero-Gallagher
Stefan Geyer
Larry Parsons
Katherine Narr
Noor Kabani
Georges Le Goualher
Jordan Feidler, The MITRE Corporation
Kenneth Smith, The MITRE Corporation
Dorret Boomsma
Hilleke Hulshoff Pol
Tyrone Cannon
Ryuta Kawashima
Bernard Mazoyer
ABSTRACT
The authors describe the development of a four-dimensional atlas and reference system that includes both macroscopic and microscopic information on structure and function of the human brain in persons between the ages of 18 and 90 years. Given the presumed large but previously unquantified degree of structural and functional variance among normal persons in the human population, the basis for this atlas and reference system is probabilistic. Through the efforts of the International Consortium for Brain Mapping (ICBM), 7,000 subjects will be included in the initial phase of database and atlas development. For each subject, detailed demographic, clinical, behavioral, and imaging information is being collected. In addition, 5,800 subjects will contribute DNA for the purpose of determining genotype- phenotype-behavioral correlations. The process of developing the strategies, algorithms, data collection methods, validation approaches, database structures, and distribution of results is described in this report. Examples of applications of the approach are described for the normal brain in both adults and children as well as in patients with schizophrenia. This project should provide new insights into the relationship between microscopic and macroscopic structure and function in the human brain and should have important implications in basic neuroscience, clinical diagnostics, and cerebral disorders.
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Publication
Published in 2001. Journal of the American Medical Informatics Association, Vol. 8, No. 5, pp. 401-430.
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