Large kernel convolutional neural network

Disclosed herein are system, method, and computer program product embodiments for generating a disease severity index based on a machine learning system executing a one-dimensional convolutional neural network (CNN) using a large kernel. An embodiment operates by collecting training data sets, extracting a training data feature set from the training data sets, weighting features in the training data feature set to generate a weighted training data feature set, selecting a large kernel comprising the weighted training data feature set, executing a one-dimensional convolution of the weighted training data feature set based on the large kernel to generate an aggregation of weighted occurrences, and generating an index based on the aggregation of weighted occurrences.

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